Published in Cancer Weekly, April 19th, 2005
According to a study from Sweden, "Control of colon cell fate in adenocarcinomas is disrupted, in part, due to aberrant Wnt/beta-catenin signaling. The nuclear receptor peroxisome PPAR-gamma has been implicated in the development of colon cancers. In the adenomatous polyposis coli multiple intestinal neoplasia (APC(Min)) mouse cancer model, PPAR-gamma expression in the colonic mucosa is markedly altered."
"In addition, PPAR-gamma protein levels are elevated, possibly through sequestration by activated...
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