Colon Cancer

Wnt/beta-catenin signaling pathway targeted PPAR-gamma activity in colon cancer

Published in Cancer Weekly, April 19th, 2005

The Wnt/beta-catenin signaling pathway supposedly targeted proliferator-activated receptor gamma (PPAR-gamma) activity in colon cancer cells.

According to a study from Sweden, "Control of colon cell fate in adenocarcinomas is disrupted, in part, due to aberrant Wnt/beta-catenin signaling. The nuclear receptor peroxisome PPAR-gamma has been implicated in the development of colon cancers. In the adenomatous polyposis coli multiple intestinal neoplasia (APC(Min)) mouse cancer model, PPAR-gamma expression in the colonic mucosa is markedly altered."

"In addition, PPAR-gamma protein levels are elevated, possibly through sequestration by activated...

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Source: Cancer Weekly (2005-04-19)

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