Cancer Weekly
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Apoptosis
Homeobox Msx1 interacts with p53 and inhibits tumor growth via apoptosis
April 19th, 2005
Homeobox Msx1 interacts with p53 and inhibits tumor growth via apoptosis. "The stability of wild-type p53 is critical for its apoptotic function. In some cancers, wild-type p53 is inactivated by interaction with viral and cellular proteins, and restoration of its activity has therapeutic potential. "Here, we identify homeobox Msx1 as a p53-interacting protein and show its novel function as a p53 regulator," investigators in South Korea report. "Overexpression of homeobox Msx1 induced apoptosis of cancer cells harboring nonfunctional wild-type p53 and suppressed growth of human tumor xenografts in nude mice," wrote K. Park and...
Source: Cancer Weekly (2005-04-19)
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