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Bone Cancer
Poly ADP-ribose polymerase inhibitors induced remodeling of chromatin
April 19th, 2005
Researchers found that poly ADP-ribose polymerase (PARP) inhibitors may induce the remodeling of chromatin in osteosarcoma cells. "This study describes the molecular mechanism by which treatment with 3-AB, a potent inhibitor of PARP, allows human osteosarcoma MG-63 cells to restrict growth and enter differentiation. Our findings show that in MG-63 cells, aberrant gene expression keeps Rb protein constitutively inactivated through hyperphosphorylation and this promotes uncontrolled proliferation of the cells," scientists in Italy reported. "After 3-AB-treatment, the poly(ADP-ribosyl)ation of nuclear proteins (PARP) markedly decreases and this results...
Source: Cancer Weekly (2005-04-19)
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