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Liver Tumorigenesis
Liver tumorigenesis modulated in connexin32-deficient mice
April 19th, 2005
Scientists found that liver tumorigenesis was modulated in connexin32 (Cx32)-deficient mice. According to recent research from the United States, "Cx32 is the major gap junction forming protein in liver. Mice deficient in Cx32 demonstrate enhanced liver tumor formation, but are resistant to promotion of hepatocarcinogenesis by the model tumor promoter phenobarbital (PB)." "Here, we re-evaluate data on the number and sizes of glucose-6-phosphatase (G6Pase)-deficient liver lesions, both in Cx32-wildtype (WT) and Cx32-null male mice, obtained from two earlier experiments with similar protocols but paradoxical outcomes," explained E.G. Luebeck and...
Source: Cancer Weekly (2005-04-19)
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