Tumorigenesis

Loss of translational control and development of human disease linked to mTOR

Published in Cancer Weekly, April 19th, 2005

The loss of translational control and the development of human disease may be linked to the mammalian target of rapamycin (mTOR).

"Many human diseases occur when the precise regulation of cell growth (cell mass/size) and proliferation (rates of cell division) is compromised. This review highlights those human disorders that occur as a result of inappropriate cellular signal transduction through mTOR, a major pathway that coordinates proper cell growth and proliferation by regulating ribosomal biogenesis and protein translation," scientists writing in the journal Seminars in Cell & Developmental Biology reported.

"Recent studies reveal that the...

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Source: Cancer Weekly (2005-04-19)

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