Tumors
HER-2/neu overexpression drives tumor proliferation but not vascularization
Published in Cancer Weekly, April 19th, 2005
"The effects of HER-2/neu overexpression on the tumor microenvironment in an aggressive breast cancer xenograft model were investigated. These studies focused on tumors derived following the subcutaneous injection of MDA-MB-435/LCC6 cells transfected with human c-erbB2 (LCC6(HER-2)) into SCID-Rag2M mice. LCC6(HER-2) tumors were more viable (H&E-stained tumor sections) than isogenic vector control tumors (LCC6(Vector))," scientists writing in the journal Molecular Cancer Research report.
"Correspondingly, a 2.7-fold increase in trypan blue-excluding cells (p=0.00056)...
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Source: Cancer Weekly (2005-04-19)
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