Cancer Weekly
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Breast Cancer
Inactive human cathepsin D triggered fibroblast invasive growth
April 19th, 2005
Inactive human cathepsin D (cath-D) was observed to trigger fibroblast invasive growth. "The aspartyl-protease cath-D is over-expressed and hypersecreted by epithelial breast cancer cells and stimulates their proliferation. As tumor epithelial-fibroblast cell interactions are important events in cancer progression, we investigated whether cath-D overexpression affects also fibroblast behavior. We demonstrate a requirement of cath-D for fibroblast invasive growth using a three-dimensional (3D) coculture assay with cancer cells secreting or not pro-cath-D," researchers in France reported. "Ectopic expression of cath-D in cath-D-deficient fibroblasts...
Source: Cancer Weekly (2005-04-19)
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