Cancer Weekly
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Lung Cancer
Smoking implicated with ERCC1 polymorphisms and an increased risk of lung cancer
April 19th, 2005
Scientists explored whether smoking might contribute to an increased risk of lung cancer. "Cigarette smoking may induce DNA damage. Lower DNA repair capacities have been associated with higher risk of lung cancer. Excision repair cross-complementing group 1 (ERCC1) is the lead enzyme in the nucleotide excision repair process, and low expression of ERCC1 mRNA levels has been associated with higher risk of cancers," investigators in the United States reported. "We examined the association between two polymorphisms of ERCC1, 8092C > A (rs3212986) and 1900TT > C (codon 118, rs11615), which are associated with altered ERCC1 mRNA stability and mRNA...
Source: Cancer Weekly (2005-04-19)
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