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Breast Cancer
Polymorphisms in XRCC1 modified polycyclic aromatic hydrocarbon-DNA adducts
April 19th, 2005
Scientists proposed that polymorphisms in XRCC1 modify polycyclic aromatic hydrocarbon (PAH)-DNA adducts, dietary antioxidants, and breast cancer risk. "The variability in DNA repair capacity of the general population may depend in part upon common variants in DNA repair genes. X-ray repair cross complementing group 1 (XRCC1) is an important DNA base excision repair gene and exhibits polymorphic variation," researchers in the United States reported. "Using the Long Island Breast Cancer Study Project, a population-based case-control study, we evaluated the hypothesis that two common single nucleotide polymorphisms of XRCC1 (codon 194 Arg->Trp and...
Source: Cancer Weekly (2005-04-19)
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