Cancer Weekly
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Oncology
Reports describe recent advances in oncology research
April 19th, 2005
Data on oncology are outlined in reports from the United States and Japan. Study 1: Tumors flourish in the presence of von Hippel-Lindau inactivation. According to a review from the United States, "germline inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene causes the von Hippel-Lindau hereditary cancer syndrome, and somatic mutations of this gene have been linked to the development of sporadic hemangioblastomas and clear-cell renal carcinomas." "The VHL tumor suppressor protein (pVHL), through its oxygen-dependent polyubiquitylation of hypoxia-inducible factor (HIF), plays a central role in the mammalian...
Source: Cancer Weekly (2005-04-19)
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