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Breast Cancer
beta-Catenin signaling in basal mammary epithelial cells leads to hyperplasia
April 19th, 2005
Activation of beta-catenin signaling in basal mammary epithelial cells ultimately can lead to hyperplasia, according to a study from France. "Wnt/beta-catenin signaling pathway is involved in the maintenance of the progenitor cell population in the skin, intestine, and other tissues, and its aberrant activation caused by stabilization of beta-catenin contributes to tumorigenesis," wrote J. Teuliere and colleagues, Institute Curie, Paris. "In the mammary gland, constitutive activation of Wnt/beta-catenin signaling in luminal secretory cells results in precocious lobuloalveolar differentiation and induces adenocarcinomas, whereas the impact of this...
Source: Cancer Weekly (2005-04-19)
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