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Mouse Skin Carcinogenesis
Antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis
April 19th, 2005
Scientists have discovered an antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis. "The levels of 8S-lipoxygenase (8S-LOX) expression and of its arachidonic acid metabolite, 8-hydroxyeicosatetraenoic acid (8-HETE), are highly elevated in the early stages of mouse skin carcinogenesis. On the other hand, several reports showing that 8-HETE is also closely associated with keratinocyte differentiation raise a question concerning the role of 8S-LOX/8-HETE in skin carcinogenesis. To address that question, here we conducted a series of gain-of-function studies," investigators in the United States reported. "Skin targeted loricrin...
Source: Cancer Weekly (2005-04-19)
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