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Aging
p53 inhabited dual role as guardian and suppressor of longevity
April 19th, 2005
Scientists claimed that p53 inhabits a dual role as both guardian and suppressor of longevity. According to published research from the United States, "The p53 tumor suppressor gene enhances longevity by inhibiting cancer development. However, Van Heemst et al. in this issue show that polymorphisms in the p53 gene may affect longevity in unexpected ways." "A meta-analysis indicates that individuals homozygous for the p53 codon 72 Pro allele instead of the more prevalent Arg allele have a modest increase in cancer incidence. This difference in cancer susceptibility is consistent with molecular studies showing that the p53 Pro polymorphic variant is a...
Source: Cancer Weekly (2005-04-19)
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