Cancer Vaccine

DNA vaccine-induced lymphoma protection dependent on anti-idiotype antibodies

Published in Cancer Weekly, April 26th, 2005

BCL1 lymphoma protection induced by idiotype DNA vaccination is entirely dependent on anti-idiotypic antibodies.

According to a study from Italy, "DNA vaccination with the idiotype (Id) of tumor B-cell membrane immunoglobulins (Ig) is a validated strategy to induce tumor protection to several mouse lymphomas. The relative contribution of anti-Id antibodies and T lymphocytes to tumor rejection is still debated. Previous studies in the BCL1 lymphoma model showed that scFv DNA immunization induces a polyclonal antibody response restricted to conformational epitopes formed by the parental V_L /V_H association. We implemented a system based on this...

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Source: Cancer Weekly (2005-04-26)

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