Colon Cancer

H-RAS V 12 and K-RAS D13 regulated radiation-induced signaling pathway function

Published in Cancer Weekly, April 26th, 2005

H-RAS V12 might induce radioresistance in HCT116 colon carcinoma cells but is heregulin dependent.

"The abilities of mutated active K-RAS and H-RAS proteins, in an isogenic human carcinoma cell system, to modulate the activity of signaling pathways following exposure to ionizing radiation is unknown," researchers in the United States reported.

"Loss of K-RAS D13 expression in HCT116 colorectal carcinoma cells blunted basal extracellular signal-regulated kinase 1/2 (ERK1/2), AKT, and c-Jun NH2-terminal kinase 1/2 activity. Deletion of the allele to express K-RAS D13 also enhanced expression of ERBB1, ERBB3, and heregulin but nearly abolished...

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Source: Cancer Weekly (2005-04-26)

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