DNA Binding

Combinatorial identification of the covalent DNA-binding polyamide tallimustine

Published in Cancer Weekly, April 26th, 2005

Researchers identified tallimustine as a covalent DNA-binding polyamide.

According to published research from the United States, "Many agents successfully used in cancer chemotherapy either directly or indirectly covalently modify DNA. Examples include cisplatin, which forms a covalent adduct with guanines, and doxorubicin, which traps a cleavage intermediate between topoisomerase II and torsionally strained DNA. In most cases, the efficacy of these drugs depends on the efficiency and specificity of their DNA binding, as well as the discrimination between normal and neoplastic cells in their handling of the drug-DNA adducts."

"While much is known...

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Source: Cancer Weekly (2005-04-26)

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