DNA Research

Nucleotide sequence variation found often in mitochondrial DNA of tumor cells

Published in Cancer Weekly, April 26th, 2005

Researchers have found a high frequency of nucleotide sequence variation in the mitochondrial DNA (mtDNA) of tumor cells.

"The mtDNA displacement loop (D-loop) regions of 76 various tumor cell lines were examined to investigate the existence of a specific relationship between a somatic mtDNA sequence and initiation and/or progression of a tumor. Based on molecular cloning-sequencing analysis, a nucleotide sequence in the D-loop region in each cell line was found to be homoplasmic. Several site-specific nucleotide variations were found in stomach and liver tumor cell lines more frequently than those in other tumor cell lines," scientists reported in the journal...

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Source: Cancer Weekly (2005-04-26)

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