Dermatology

Antisense oligodeoxynucleotide G3139 activates melanoma cell apoptosis

Published in Cancer Weekly, April 26th, 2005

Antisense oligodeoxynucleotide G3139 activates melanoma cell apoptosis.

"In a previous study, we showed that G3139, an antisense phosphorothioate oligonucleotide that down-regulates the expression of Bcl-2 protein, did not cause chemosensitization of 518A2 melanoma cells," scientists in the United States report.

"In this work, we show that G3139, and the 2-base mismatch, G4126, can initiate apoptosis in this and other melanoma cell lines as shown by increased cell surface Annexin V expression, typical nuclear phenotypic changes as assessed by 4',6-diamidino-2-phenylindole staining, activation of caspase-3 (but not caspase-8) and Bid, appearance of...

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Source: Cancer Weekly (2005-04-26)

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