Drug Development

Fumigillin derivative CKD-732 is safe at presumed clinical doses

Published in Cancer Weekly, April 26th, 2005

Fumigillin derivative CKD-732 is safe at presumed clinical doses.

"CKD-732[16-O-(4-dimethylaminoethoxy) cinnamoyl fumagillol hemioxalate] is a new fumagillin anticancer drug that belongs to an angiogenesis inhibitor. Its effect on the central nervous system (CNS), general behavior, cardiovascular-respiratory system and the other organ systems were studied," investigators in South Korea report.

"CKD-732 was intravenously administered with the dosages of 10, 30, 40 or 50 mg/kg and the highest dosage of 50 mg/kg prolonged the hexobarbital-induced sleep time," wrote E.J. Kim and colleagues, Korea Research Institute of Chemical Technology, Korea Institute...

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Source: Cancer Weekly (2005-04-26)

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