Endocervical Adenocarcinomas

Metastatic tumors can appear to be ovarian surface epithelial neoplasms

Published in Cancer Weekly, April 26th, 2005

Metastatic endocervical adenocarcinomas can appear to be ovarian surface epithelial neoplasms, but the presence of human papillomavirus DNA belies their origins, say Johns Hopkins University Hospital pathologists.

"The vast majority of endocervical adenocarcinomas are high-risk human papillomavirus (HPV)-related neoplasms, characterized by p16 expression and frequent loss of hormone receptor expression, which infrequently metastasize to the ovaries. We report 10 cases of endocervical adenocarcinomas with ovarian metastases in which the ovarian tumors simulated primary ovarian surface epithelial neoplasms," wrote E. Elishaev and colleagues.

They...

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Source: Cancer Weekly (2005-04-26)

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