Gap Junctions

Novel GAP-like protein examined, influence on connexin revealed

Published in Cancer Weekly, April 26th, 2005

According to published research from the United States, a novel rab GAP-like protein interacts with connexin and induces its degradation.

"Gap junctions play critical roles in tissue function and homeostasis. Connexin43 (Cx43) is a major gap junction protein expressed in the mammalian heart and other tissues and may be regulated by its interaction with other cellular proteins.

"Using the yeast two-hybrid screen, we identified a novel Cx43-interacting protein of 85-kDa, CIP85, which contains a single TBC, SH3, and RUN domain, in addition to a short-coiled coil region," wrote Z. Lan and colleagues, Cancer Research Center of Hawaii.

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Source: Cancer Weekly (2005-04-26)

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