Apoptosis

Peripheral-type benzodiazepine receptor ligands amplified neuronal apoptosis

Published in Cancer Weekly, April 26th, 2005

Peripheral-type benzodiazepine receptor (PBR) ligands might amplify neuronal apoptosis.

According to recent research published in the journal Apoptosis, "The mitochondrial PBR is involved in a functional structure designated as the mitochondrial permeability transition (MPT) pore, which controls apoptosis. PBR expression in the nervous system has been reported in glial and immune cells."

"We now show expression of both PBR mRNA and protein, and the appearance of binding of a synthetic ligand fluo-FGIN-1-27 in mitochondria of rat cerebellar granule cells (CGCs). Additionally, the effect of PBR ligands on colchicine-induced apoptosis was...

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Source: Cancer Weekly (2005-04-26)

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