Genetics and Genomics

Gene expression during mouse colon embryonic development characterized

Published in Cancer Weekly, April 26th, 2005

Microarray analysis has been used to identify murine genes involved in embryonic colon development.

"During late embryogenesis, the mouse colon develops from a pseudostratified, undifferentiated endoderm to a single-layered columnar epithelium with accompanying mesenchymal maturation," scientists in the United States explained.

"To identify regulatory genetic programs underlying these morphological changes," Y.K. Park and colleagues at Vanderbilt University "profiled gene expression of the developing mouse colon by microarray from embryonic day (E)13.5 to E18.5."

"Unbiased cluster analysis of 13,484 cDNA elements revealed two...

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Source: Cancer Weekly (2005-04-26)

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