Lung Cancer

Major vault protein does not play a role in chemoresistance or drug localization

Published in Cancer Weekly, April 26th, 2005

Scientists have found that major vault protein (MVP) does not play a role in chemoresistance or drug localization in a nonsmall cell lung cancer cell line.

"The human MVP is the primary component of the 13 MDa vault complex. MVP has been implicated in the development of non-P-glycoprotein-mediated drug resistance in cancer cells. Here we present several lines of evidence that dispute this assertion," investigators in the United States reported.

"Small interfering RNA (siRNAs) capable of specifically and efficiently knocking down expression of MVP do not alter the ability of resistant cells to remove doxorubicin from the nucleus and do not increase...

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Source: Cancer Weekly (2005-04-26)

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