Melanoma

Hepatocyte growth factor induced fibronectin matrix synthesis in melanoma cells

Published in Cancer Weekly, April 26th, 2005

Scientists proposed that HGF induced fibronectin matrix synthesis in melanoma cells through the MAP kinase-dependent signaling pathway and induction of Egr-1.

According to published research from France, "The matrix fibronectin protein is a multifunctional adhesive molecule that promotes migration and invasiveness of many tumors including melanomas. Increased fibronectin synthesis has been associated with the metastatic potential of melanoma cells; however, the molecular mechanisms underlying fibronectin overexpression during melanoma development are poorly understood."

"We report that hepatocyte growth factor/scatter factor (HGF) induces fibronectin...

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Source: Cancer Weekly (2005-04-26)

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