Melanoma

UV exposure, genetic targets in melanocytic tumors, and transgenic mouse models

Published in Cancer Weekly, April 26th, 2005

Scientists discussed ultraviolet (UV) exposure, genetic targets in melanocytic tumors, and transgenic mouse models.

According to recent research published in the journal Photochemistry and Photobiology, "The genetic changes and corruption of kinase activity in melanomas appear to revolve around a central axis: mitogenic signaling along the RAS pathway down to transcription regulation by pRB. Epidemiological studies point to the importance of UV radiation in the etiology of melanoma, but where and how UV radiation is targeted to contribute to the oncogenic signaling remains obscure. Animal models of melanoma genesis could serve to clarify this issue, but many of...

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Source: Cancer Weekly (2005-04-26)

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