Melanoma Vaccine

Invasive melanoma cells induce metalloproteinase synthesis in fibroblasts

Published in Cancer Weekly, April 26th, 2005

High invasive melanoma cells induce matrix metalloproteinase-1 synthesis in fibroblasts by interleukin-1 alpha and basic fibroblast growth factor-mediated mechanisms.

According to a study from Germany, "Tumor invasion and metastasis of melanoma have been shown to require proteolytic degradation of the extracellular environment, achieved primarily by enzymes of the matrix metalloproteinases (MMP) family. Increased enzyme activity is localized at the border of tumor cells and the adjacent peritumoral connective tissue, emphasizing the crucial role of tumor-stroma interactions in the regulation of MMP activity. To analyze whether direct cell-cell contacts of melanoma cells...

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Source: Cancer Weekly (2005-04-26)

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