Oncology

Chimeric enhancer controls adenovirus-based prostate cancer gene therapy

Published in Cancer Weekly, April 26th, 2005

Chimeric enhancer controls adenovirus-based prostate cancer gene therapy.

According to published research from the United States, "PSES is a chimeric enhancer containing enhancer elements from prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSMA) genes that are prevalently expressed in androgen-independent prostate cancers. PSES shows strong activity equivalent to cytomegalovirus (CMV) promoter, specifically in PSA/PSMA-positive prostate cancer cells, the major cell types in prostate cancer in the absence of androgen."

"We developed a recombinant adenovirus (AdE4PSESE1a) by placing adenoviral E1a and E4 genes under the control...

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Source: Cancer Weekly (2005-04-26)

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