Oral Cancer

Cyclin D1 polymorphism associated with increased susceptibility to oral cancer

Published in Cancer Weekly, April 26th, 2005

The cyclin D1 polymorphism is associated with an increased susceptibility to oral cancer.

"We have examined the association of the CCND1 A/G(870) polymorphism with susceptibility and outcome in 174 German patients with oral SCC (OSCC).

"The CCND1 G 870 allele frequency was increased in cases (G(870)=0.65) when compared to controls (n=155, G(870)=0.54) and the distribution of CCND1 genotypes were significantly different (p=0.014)," scientists writing in the journal Oral Oncology report.

"Using logistic regression, correcting for age, gender and tobacco consumption, an increased frequency of the CCND1 GG(870) genotype was...

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Source: Cancer Weekly (2005-04-26)

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