Skin Cancer

Increased apoptosis led to decreased skin cancer in UV-irradiated CD1d-/- mice

Published in Cancer Weekly, April 26th, 2005

An increase in apoptosis might result in a decrease in skin cancer.

According to published research from Japan, "We previously demonstrated that CD1d knockout mice were resistant to ultraviolet (UV)-induced immunosuppression. Because immune suppression is a critical factor in the development of UV-induced skin cancers, we investigated the response of wild type (WT) and CD1d(-/-) mice to UV carcinogenesis. We found that although 100% of WT mice developed skin tumors after 45 weeks of UV irradiation, only 60% of CD1d(-/-) mice developed skin tumors."

"To investigate the mechanisms involved in the resistance of CD1d(-/-) mice to UV-induced...

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Source: Cancer Weekly (2005-04-26)

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