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Stem Cell Transplantation

Younger age/days of apheresis/male gender predict increased yield of CD34+ cells

Published in Cancer Weekly, April 26th, 2005

Younger age, days of apheresis and male gender predict increased yield of CD34+ cells.

"The use of peripheral blood stem cells (PBSC) for allogeneic transplants in adults has greatly increased. This trend is reflected in pediatrics, where healthy children increasingly are donating PBSC or donor lymphocyte infusion (DLI) via apheresis for use by ill siblings.

"There is a potential concern that the risks of PBSC collection may differ for pediatric donors. However, no large studies have assessed safety issues in this population," researchers in the United States report.

"To address this need, we reviewed 218 (213 PBSC, 5 DLI)...

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