Tumor Suppression

Role of PP2A as tumor suppressor inspected

Published in Cancer Weekly, April 26th, 2005

Scientists have inspected the role of PP2A as a tumor suppressor.

"PP2A is one of the few serine/threonine-specific phosphatases in the cell, and its complex structure and regulation guarantees its many different functions," researchers in Belgium reported.

"Some viruses have chosen to target this enzyme system in order to manage the host cell machinery for their own profit and to program cells into a malignant state," emphasized V. Janssens and colleagues, Katholieke University of Leuven.

The researchers concluded, "Suppression of PR61/B'-gamma, a specific third regulatory subunit of PP2A, can substitute for the viral SV40...

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Source: Cancer Weekly (2005-04-26)

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