Cervical Cancer

Estrogen plays etiological role in HPV-transgenic mouse model

Published in Cancer Weekly, April 26th, 2005

Estrogen plays etiological role in cervical cancer in a human papillomavirus-transgenic mouse model.

"Cervical cancer is a leading cause of death by cancer among women worldwide. High-risk human papillomaviruses (HPVs) are the major etiological agents for cervical cancer, but other factors likely contribute to cervical cancer, because these cancers commonly arise decades after initial exposure to HPV. Estrogen is thought to be one such cofactor; however, its temporal requirements in human cervical cancer are not known," wrote T. Brake and colleagues, University of Wisconsin.

In their study, Brake's group assessed "the temporal requirements of...

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Source: Cancer Weekly (2005-04-26)

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