Published in Cancer Weekly, April 26th, 2005
"Several investigations have supposed that tumor suppressor genes might be located on human chromosome 8. We used microcell-mediated transfer of chromosome 8 into MDA-MB-231 breast cancer cells and generated independent hybrids with strongly reduced tumorigenic potential. Loss of the transferred chromosome results in reappearance of the malignant phenotype," scientists writing in the journal Oncogene report.
"Expression analysis identified a set of 109 genes...
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