Cancer Cell Inhibitors

Novel inhibitors of human histone deacetylases discovered

Published in Cancer Weekly, April 26th, 2005

Scientists discovered novel inhibitors of human histone deacetylases.

According to published research from Japan, "To find novel non-hydroxamate histone deacetylase (HDAC) inhibitors, a series of compounds modeled after suberoylanilide hydroxamic acid (SAHA) was designed and synthesized. In this series, compound 7, in which the hydroxamic acid of SAHA is replaced by a thiol, was found to be as potent as SAHA, and optimization of this series led to the identification of HDAC inhibitors more potent than SABA. In cancer cell growth inhibition assay, S-isobutyryl derivative 51 showed strong activity, and its potency was comparable to that of SAHA."

"The...

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Source: Cancer Weekly (2005-04-26)

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