Cancer Cell Morphogenesis

Tetraspanin CD82 attenuated cellular morphogenesis

Published in Cancer Weekly, April 26th, 2005

Tetraspanin CD82 was suggested to attenuate cellular morphogenesis through downregulating integrin alpha 6-mediated cell adhesion.

According to a study from the United States, "Tetraspanin CD82 has been implicated in integrin-mediated functions such as cell motility and invasiveness. Although tetraspanins associate with integrins, it is unknown if and how CD82 regulates the functionality of integrins. In this study, we found that DUl45 prostate cancer cells underwent morphogenesis on the reconstituted basement membrane Matrigel to form an anastomosing network of multicellular structures."

"This process entirely depends on integrin alpha6, a receptor...

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Source: Cancer Weekly (2005-04-26)

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