Cancer Cell Survival

H-RAS and K-RAS associated with cell survival

Published in Cancer Weekly, April 26th, 2005

Activated forms of H-RAS and K-RAS might differentially regulate membrane associations and affect therapeutic kinase inhibitors on cell survival.

According to recent research published in the journal Molecular Cancer Therapeutics, "The abilities of mutated active RAS proteins to modulate cell survival following exposure to ionizing radiation and small molecule kinase inhibitors were examined."

"Homologous recombination in HCT116 cells to delete the single allele of K-RAS D13 resulted in a cell line that exhibited an approximate 75% reduction in basal extracellular signal-regulated kinase 1/2, AKT, and c-jun-NH2-kinase 1/2 activity....

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Source: Cancer Weekly (2005-04-26)

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