Acute Promyelocytic Leukemia

Sumoylation site in PML/RARA deemed essential for leukemic transformation

Published in Cancer Weekly, April 26th, 2005

Scientists have deemed a sumoylation site in PML/RARA to be essential for leukemic transformation.

According to published research from France, "Pathogenesis of acute promyelocytic leukemia (APL) has been proposed to involve transcriptional repression through enhanced corepressors binding onto RARA moieties of PML/RARA homodimers."

"Unexpectedly, we show that the K160 sumoylation site in the PML moiety of PML/RARA is required for efficient immortalization/differentiation arrest ex vivo, implying that RARA homodimerization is insufficient to fully immortalize primary hematopoietic progenitor cells," described J. Zhu and colleagues, University of...

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Source: Cancer Weekly (2005-04-26)

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