Cancer Survival

Increase in S100A4 associated with decrease in cancer survival

Published in Cancer Weekly, April 26th, 2005

Because of the adverse association between S100A4 and cancer survival, scientists used S100A1 to affect S100A4 function.

According to recent research from England, "Increased levels of the homodimeric calcium-binding protein, S100A4, have been shown to cause a metastatic phenotype in at least three independent model systems of breast cancer and its presence in carcinoma cells has been shown to be associated with a reduction in the survival of patients suffering from a range of different cancers. S100A4 has been shown to interact in vitro with another member of the S100 family of proteins, S100A1. The purpose of the present study was to find out whether S100A1 could...

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Source: Cancer Weekly (2005-04-26)

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