Cancer Therapy

Antidepressant chlorimipramine reported to kill human glioma cells in vitro

Published in Cancer Weekly, April 26th, 2005

The antidepressant chlorimipramine has been reported to kill human glioma cells in vitro.

"Mitochondria have been suggested to be a potential intracellular target for cancer chemotherapy," scientists in England report. "In this report, we demonstrate the ability of the tricyclic antidepressant chlorimipramine to kill human glioma cells in vitro by a molecular mechanism resulting in an increase in caspase 3 activity following inhibition of glioma oxygen consumption.

"Studies with isolated rat mitochondria showed that chlorimipramine specifically inhibited mitochondrial complex III activity, which causes decreased mitochondrial membrane potential as...

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Source: Cancer Weekly (2005-04-26)

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