Published in Cancer Weekly, April 26th, 2005
"Mitochondria have been suggested to be a potential intracellular target for cancer chemotherapy," scientists in England report. "In this report, we demonstrate the ability of the tricyclic antidepressant chlorimipramine to kill human glioma cells in vitro by a molecular mechanism resulting in an increase in caspase 3 activity following inhibition of glioma oxygen consumption.
"Studies with isolated rat mitochondria showed that chlorimipramine specifically inhibited mitochondrial complex III activity, which causes decreased mitochondrial membrane potential as...
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