Published in Cancer Weekly, April 26th, 2005
Scientists at the Mayo Clinical College of Medicine have shown that "live attenuated measles viruses of the Edmonston lineage (MV-Edm) have potent antitumor activity(1-4) but are not entirely tumor-specific owing to widespread distribution of their native receptors, CD46(5,6) and SLAM(7- 9). We have therefore developed a pseudoreceptor system that allows rescue and propagation of fully retargeted viruses displaying single-chain antibody fragments.
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