Cancer Therapy
Antitumor activity of measles virus studied
Published in Cancer Weekly, April 26th, 2005
Scientists at the Mayo Clinical College of Medicine have shown that "live attenuated measles viruses of the Edmonston lineage (MV-Edm) have potent antitumor activity(1-4) but are not entirely tumor-specific owing to widespread distribution of their native receptors, CD46(5,6) and SLAM(7- 9). We have therefore developed a pseudoreceptor system that allows rescue and propagation of fully retargeted viruses displaying single-chain antibody fragments.
"Viruses retargeted to tumor-selective CD38, epidermal growth factor receptor (EGFR), or EGFR mutant vIII (EGFRvIII) efficiently entered cells...
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Source: Cancer Weekly (2005-04-26)
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