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Cancer Therapy

Liver-selective thyromimetic KAT-681 prevents liver tumors in rodent models

Published in Cancer Weekly, May 3rd, 2005

Liver-selective thyromimetic KAT-681 prevents liver tumors in rodent models.

According to scientists in Japan, "we recently reported that short-term treatment with KAT-681 (KAT), a liver-selective thyromimetic, inhibits the development of preneoplastic lesions in rat livers and may be a candidate chemo-preventive agent for hepatocarcinogenesis."

"In this study, time-course observations of hepatocellular proliferative lesions were carried out during short-term and long-term treatment with KAT to investigate its anti-hepatocarcinogenic effects. The hepatocellular proliferative lesions in male F344 rats were induced by the initiation treatment of...

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