Published in Cancer Weekly, May 3rd, 2005
Study 1: Doxazosin halts vascular endothelial cell adhesion, migration, and invasion.
"The quinazoline-derived alpha1-adrenoceptor antagonists doxazosin and terazosin have been recently shown to induce an anoikis effect in human prostate cancer cells and to suppress prostate tumor vascularity in clinical specimens [Keledjian and Kyprianou, 2003]. This study sought to examine the ability of doxazosin to affect the growth of human vascular endothelial cells and to modulate vascular endothelial growth factor (VEGF)-mediated angiogenesis," scientists in...
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