Colon Cancer

Interleukin-1 beta and TNF-alpha upregulated interleukin-23 subunit p19 gene

Published in Cancer Weekly, May 10th, 2005

Interleukin-1 beta and TNF-alpha was suggested to upregulate interleukin-23 (IL-23) subunit p19 gene expression in colon cancer cells.

According to recent research from Japan, "The recently identified cytokine IL-23 consists of p19 and p40 subunits. The major cellular source of IL-23 is dendritic cells and/or macrophages. We investigated the expression of IL-23 p19 mRNA in human colonic subepithelial myofibroblasts (SEMFs)."

"p19 mRNA was not expressed in unstimulated SEMFs, but IL-1beta and TNF-alpha strongly induced p19 mRNA expression in these cells. The effects of IL-1B were much stronger than those of TNF-alpha. These responses were observed in...

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Source: Cancer Weekly (2005-05-10)

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