Dermatology
Mutant B-V599E-RAF regulates melanoma growth and vascularization
Published in Cancer Weekly, May 10th, 2005
"Activating mutations of the B-PIAF gene are observed in >60% of human melanomas. Approximately 90% of these mutations occur in the activation segment of the kinase domain as a single-base substitution that converts a valine to glutamic acid at codon 599 (V599E) in exon 15," scientists in the united states report.
"This mutation causes activation of the kinase as well as downstream effectors of the mitogen-activated protein kinase-signaling cascade, leading to melanoma tumor development by an as yet unknown mechanism," noted A. Sharma and colleagues, Pennsylvania State University,...
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Source: Cancer Weekly (2005-05-10)
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