Published in Cancer Weekly, May 10th, 2005
"Apoptotic evasion is a hallmark of cancer and its resistance to chemotherapeutic drugs. Identification of cellular proteins that mediate apoptotic programs is a critical step toward the development of therapeutics aimed at overcoming apoptosis resistance."
"We developed an innovative high-throughput screen to identify proteins that modulate Fas ligand-mediated apoptosis using fluorophore-assisted light inactivation (HTS-FALIpop)," researchers in the United States report.
"The FALI protein knockdown strategy was coupled to a caspase activity assay...
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