Apoptosis
Cyclooxygenase-2 inhibits ginseng metabolite-mediated apoptosis
Published in Cancer Weekly, May 10th, 2005
"Recently, a novel intestinal bacterial metabolite of ginseng protopanaxadiol saponins, i.e., 20-0-(beta-D-glucopyranosyl)20(S)-protopanaxadiol (1H-901), has been reported to induce apoptosis in a variety of cancer cells. Here we show a differential effect of IH-901 on several cell types.
"Exposure to IH-901 for 48 hours at a supposedly subapoptotic concentration of 40 mcM/L led to both apoptotic cell death and G(1) arrest in Hep3B cells, but only resulted in G(1) arrest in MDAMB-231, Hs578T, and MKN28 cells," scientists in South Korea report.
"Additionally," said...
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Source: Cancer Weekly (2005-05-10)
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