Leukemia

Methylation of histones in leukemia used as marker of granulocyte abnormalities

Published in Cancer Weekly, May 10th, 2005

Methylation of histones in myeloid leukemia could be used as a potential marker of granulocyte abnormalities.

"We show that common heterochromatin antigenic protein markers [HPlalpha, -beta, -y and mono-, di-, and trimethylated histone 113 lysine 9 (H3K9)], although present in human blood progenitor CD34+ cells, differentiated lymphocytes, and monocytes, are absent in neutrophil granulocytes and to large extent, in eosinophils," investigators in Czech Republic reported.

"Monomethylated and in particular, dimethylated H3K9 are present to variable degrees in the granulocytes of chronic myeloid leukemia (CML) patients, without being accompanied by UPl...

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Source: Cancer Weekly (2005-05-10)

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