Lung Cancer

Retrovirus envelope protein induces lung tumors in mice

Published in Cancer Weekly, May 10th, 2005

A sheep retrovirus envelope protein is enough to trigger tumor formation in the lungs of immunodeficient mice, according to new research from the Fred Hutchinson Cancer Research Center, University of Washington, Seattle. This is the first example of a retroviral structural protein that induces tumorigenesis.

Jaagsiekte sheep retrovirus, which killed Dolly, the famous cloned sheep, causes a contagious lung cancer in sheep and goats that can lead to a significant loss of livestock. Although it has previously been shown that the viral envelope protein can transform cells in culture, the mechanism for tumor formation remains unknown.

Dusty Miller and...

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Source: Cancer Weekly (2005-05-10)

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