Oncology
Death ligands use tumor hypoxia to coerce sensitivity to chemotherapy
Published in Cancer Weekly, May 10th, 2005
"Death ligands such as CD95 ligand (CD95L) have limited activity against glioma cells under normoxic conditions. Hypoxia is a critical aspect of the microenvironment of gliomas in vivo. We investigated the effect of co-exposure to acute hypoxia and CD95 ligand in three human malignant glioma cell lines with different susceptibility to CD95L under normoxic conditions," scientists writing in the Journal of Neurochemistry report.
"Hypoxia sensitized all three cell lines towards CD95L-induced cell death. Co-exposure resulted in apoptotic changes in the early phase, with gradual...
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Source: Cancer Weekly (2005-05-10)
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